Effective pharmacy item master management within an Electronic Health Record (EHR) system is critical for streamlining operations, improving medication safety, and ensuring compliance. This session will focus on best practices for cleaning up non-formulary items and optimizing the pharmacy item master to enhance accuracy and efficiency. Attendees will learn strategies to identify and remove obsolete or duplicate items, maintain formulary integrity, and implement sustainable governance processes. Designed for pharmacy professionals and informatics specialists, this session will provide actionable insights to reduce medication errors, improve ordering workflows, and support clinical decision-making.